Article
Non-modulation as an intermediate phenotype in essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 1992
Williams G H, Dluhy R G, Lifton R P, Moore T J, Gleason R, Williams R, Hunt S C, Hopkins P N, Hollenberg N K
Abstract excerpt
Non-modulation is a trait characterized by abnormal angiotensin-mediated control of aldosterone release and the renal blood supply. To determine whether non-modulation defines a specific subgroup of the hypertensive population and its utility as an intermediate phenotype, we have studied the distribution of this quantitative trait, whether its features are reproducible on repeated testing, and whether there is...
Topics
- Adrenal Glands
- Adult
- Aldosterone
- Angiotensin II
- Female
- Humans
- Hypertension
- Male
- Middle Aged
- Phenotype
- Regional Blood Flow
- Renal Circulation