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Article

Increased formation of angiotensin II from angiotensin I in individuals of African descent.

Journal of hypertension - 1 Aug 2025

Gandhi Sanjay K, Kim Kyung-Soo, Brosnihan K Bridget, Brown Nancy J

Abstract excerpt

OBJECTIVE: Activation of the renin-angiotensin-aldosterone system (RAAS) and African ancestry are both associated with increased end-organ damage in hypertension. An insertion (I)/deletion (D) polymorphism in the gene encoding the angiotensin-converting enzyme (ACE) has been associated with ACE activity. This study tested the hypothesis that ancestry or ACE I/D genotype affects the conversion of angiotensin (Ang)...

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Identifiers

PMID: 40509687
DOI: 10.1097/HJH.0000000000004068

Genes

ACE

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