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Article

Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.

American journal of hypertension - 1 Apr 2009

Tripodi Grazia, Citterio Lorena, Kouznetsova Tatiana, Lanzani Chiara, Florio Monica, Modica Rossana, Messaggio Elisabetta, Hamlyn John M, Zagato Laura, Bianchi Giuseppe, Staessen Jan A, Manunta Paolo

Abstract excerpt

BACKGROUND: Endogenous ouabain (EO) has been linked with long-term changes in sodium balance and cardiovascular structure and function. The biosynthesis of EO involves, cholesterol side-chain cleavage (CYP11A1), 3-beta-hydroxysteroid dehydrogenase (HSD3B) with sequential metabolism of pregnenolone and progesterone. Furthermore, the renal excretion of cardiac glycosides is mediated by the organic anion transporter...

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Share to 3-Hydroxysteroid Dehydrogenases
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cholesterol Side-Chain Cleavage Enzyme

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Source

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Identifiers

PMID: 19197249
DOI: 10.1038/ajh.2009.3
PMCID: PMC3518306

Genes

DBP
PGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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