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Article

Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2016

Lanzani Chiara, Gatti Guido, Citterio Lorena, Messaggio Elisabetta, Delli Carpini Simona, Simonini Marco, Casamassima Nunzia, Zagato Laura, Brioni Elena, Hamlyn John M, Manunta Paolo

Abstract excerpt

Circulating levels of endogenous ouabain (EO), a vasopressor hormone of adrenocortical origin, are increased by sodium depletion. Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocortical cells. Here, we investigated the hypothesis that lanosterol synthase rs2254524 alleles in vivo impact the blood...

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PMID: 26667413
DOI: 10.1161/HYPERTENSIONAHA.115.06415
PMCID: PMC4713326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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