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Article

Alloreactive Memory T Cells Are Responsible for the Persistence of Graft-versus-Host Disease

1 Mar 2005

Abstract excerpt

Graft-vs-host disease (GVHD) is caused by a donor T cell anti-host reaction that evolves over several weeks to months, suggesting a requirement for persistent alloreactive T cells. Using the C3H.SW anti-C57BL/6 (B6) mouse model of human GVHD directed against minor histocompatibility Ags, we found that donor CD8(+) T cells secreting high levels of IFN-gamma in GVHD B6 mice receiving C3H.SW naive CD8(+) T cells...

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Identifiers

PMID: 15728519
DOI: 10.4049/jimmunol.174.5.3051

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