Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.

doi:10.1101/gr.123109.111

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Article

Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.

Genome research - 1 Feb 2012

Wang Linghua, Tsutsumi Shuichi, Kawaguchi Tokuichi, Nagasaki Koichi, Tatsuno Kenji, Yamamoto Shogo, Sang Fei, Sonoda Kohtaro, Sugawara Minoru, Saiura Akio, Hirono Seiko, Yamaue Hiroki, Miki Yoshio, Isomura Minoru, Totoki Yasushi, Nagae Genta, Isagawa Takayuki, Ueda Hiroki, Murayama-Hosokawa Satsuki, Shibata Tatsuhiro, Sakamoto Hiromi, Kanai Yae, Kaneda Atsushi, Noda Tetsuo, Aburatani Hiroyuki

Abstract excerpt

Whole-exome sequencing (Exome-seq) has been successfully applied in several recent studies. We here sequenced the exomes of 15 pancreatic tumor cell lines and their matched normal samples. We captured 162,073 exons of 16,954 genes and sequenced the targeted regions to a mean coverage of 56-fold. This study identified a total of 1517 somatic mutations and validated 934 mutations by transcriptome sequencing. We...

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Identifiers

PMID: 22156295
DOI: 10.1101/gr.123109.111
PMCID: PMC3266029

Genes

MLH1
PBRM1
TGFBR2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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