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Article

High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.

Investigative ophthalmology & visual science - 9 Oct 2012

Daniels Anthony B, Lee Joo-Eun, MacConaill Laura E, Palescandolo Emanuele, Van Hummelen Paul, Adams Scott M, DeAngelis Margaret M, Hahn William C, Gragoudas Evangelos S, Harbour J William, Garraway Levi A, Kim Ivana K

Abstract excerpt

PURPOSE: We assessed for mutations in a large number of oncogenes and tumor suppressor genes in primary uveal melanomas using a high-throughput profiling system. METHODS: DNA was extracted and purified from 134 tissue samples from fresh-frozen tissues (n = 87) or formalin-fixed, paraffin-embedded tissues (n = 47) from 124 large uveal melanomas that underwent primary treatment by enucleation. DNA was subjected to...

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Source

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Identifiers

PMID: 22977135
DOI: 10.1167/iovs.12-10427
PMCID: PMC3471553

Genes

GNA11
GNAQ
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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