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Article

Lack of GNAQ germline mutations in uveal melanoma patients with high risk for hereditary cancer predisposition.

Familial cancer - 1 Jun 2011

Abdel-Rahman Mohamed H, Pilarski Robert, Massengill James B, Christopher Benjamin B, Davidorf Frederick H

Abstract excerpt

A high frequency of somatic mutation in GNAQ has been reported in uveal melanoma (UM). GNAQ is located in the chromosomal band 9q21, the same chromosomal band that harbors a putative candidate gene for hereditary UM. We investigated the frequency of germline sequence alterations in the GNAQ gene in UM patients with increased predisposition to hereditary cancer. A total of 44 high risk UM patients were studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21072599
DOI: 10.1007/s10689-010-9401-2

Genes

GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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