Article
GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.
European journal of cancer (Oxford, England : 1990) - 1 Sept 2016
Sheng Xinan, Kong Yan, Li Yiqian, Zhang Qiannan, Si Lu, Cui Chuanliang, Chi Zhihong, Tang Bixia, Mao Lili, Lian Bin, Wang Xuan, Yan Xieqiao, Li Siming, Dai Jie, Guo Jun
Abstract excerpt
BACKGROUND: Mucosal melanoma (MM) is a rare subtype of melanoma in Caucasians with extremely poor prognosis, and therapy strategy has not been clearly established for MM. We aimed to investigate the genetic aberrations possibly applicable in targeted therapy of MM. We examined the somatic mutations of GNAQ and GNA11 (GNAQ/11, encoding the guanine nucleotide-binding alpha subunits) in MM and evaluated their...
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