Article
Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms.
Trends in pharmacological sciences - 1 Jan 2018
Jespers Willem, Schiedel Anke C, Heitman Laura H, Cooke Robert M, Kleene Lisa, van Westen Gerard J P, Gloriam David E, Müller Christa E, Sotelo Eddy, Gutiérrez-de-Terán Hugo
Abstract excerpt
The four adenosine receptors (ARs), A1, A2A, A2B, and A3, constitute a subfamily of G protein-coupled receptors (GPCRs) with exceptional foundations for structure-based ligand design. The vast amount of mutagenesis data, accumulated in the literature since the 1990s, has been recently supplemented with structural information, currently consisting of several inactive and active structures of the A2A and inactive...
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