Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

Abstract excerpt

To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow interpretation and prediction of individual responses to drug treatment. For G-protein coupled receptors systematic mutagenesis has provided the major part of functional...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Ligands
• Share to Mutant Proteins