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Article

Biophysical mapping of the adenosine A2A receptor.

Journal of medicinal chemistry - 14 Jul 2011

Zhukov Andrei, Andrews Stephen P, Errey James C, Robertson Nathan, Tehan Benjamin, Mason Jonathan S, Marshall Fiona H, Weir Malcolm, Congreve Miles

Abstract excerpt

A new approach to generating information on ligand receptor interactions within the binding pocket of G protein-coupled receptors has been developed, called Biophysical Mapping (BPM). Starting from a stabilized receptor (StaR), minimally engineered for thermostability, additional single mutations are then added at positions that could be involved in small molecule interactions. The StaR and a panel of binding...

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PMID: 21661720
DOI: 10.1021/jm2003798
PMCID: PMC3308198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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