Article

A new platform for high-throughput therapy testing on iPSC-derived, immature airway from Cystic Fibrosis Patients

2021-07-05

Abstract excerpt

Induced pluripotent, stem cell (iPSC)-derived models of airway tissue have successfully modeled the primary defect in regulated chloride conductance caused by the major Cystic Fibrosis causing mutation, F508del. However, it remains unclear if iPSC-derived airway cultures can be used in high-throughput therapy development for F508del and rarer mutations. There is an urgent need for airway tissue models that reflect...

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Literature Corpus work: 27f2184e-4db6-52e7-946f-5706f71a7e38
DOI: 10.1101/2021.07.05.451013

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