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Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients.

Journal of psychiatric research - 1 Nov 2011

Sasayama Daimei, Wakabayashi Chisato, Hori Hiroaki, Teraishi Toshiya, Hattori Kotaro, Ota Miho, Ishikawa Masanori, Arima Kunimasa, Higuchi Teruhiko, Amano Naoji, Kunugi Hiroshi

Abstract excerpt

Recent studies indicate a role of excessive interleukin-6 (IL-6) signaling in the pathogenesis of schizophrenia. A previous study reported a significant association of schizophrenia with the IL-6 receptor (IL-6R) gene Asp358Ala polymorphism, which is known to regulate circulating IL-6 and soluble IL-6R (sIL-6R) levels in healthy subjects. To further examine the influence of the polymorphism in schizophrenic...

Topics

Adult
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-6
Male
Middle Aged
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Interleukin-6

Risk Factors

Schizophrenia

Source

Identifiers

PMID: 21700295
DOI: 10.1016/j.jpsychires.2011.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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