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Article

Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients.

Journal of psychiatric research - 1 Nov 2011

Sasayama Daimei, Wakabayashi Chisato, Hori Hiroaki, Teraishi Toshiya, Hattori Kotaro, Ota Miho, Ishikawa Masanori, Arima Kunimasa, Higuchi Teruhiko, Amano Naoji, Kunugi Hiroshi

Abstract excerpt

Recent studies indicate a role of excessive interleukin-6 (IL-6) signaling in the pathogenesis of schizophrenia. A previous study reported a significant association of schizophrenia with the IL-6 receptor (IL-6R) gene Asp358Ala polymorphism, which is known to regulate circulating IL-6 and soluble IL-6R (sIL-6R) levels in healthy subjects. To further examine the influence of the polymorphism in schizophrenic...

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PMID: 21700295
DOI: 10.1016/j.jpsychires.2011.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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