Article
NaV1.7 and pain: contribution of peripheral nerves.
Pain - 1 Mar 2018
Hoffmann Tal, Sharon Ohad, Wittmann Jürgen, Carr Richard W, Vyshnevska Alina, Col Roberto De, Nassar Mohammed A, Reeh Peter W, Weidner Christian
Abstract excerpt
The sodium channel NaV1.7 contributes to action potential (AP) generation and propagation. Loss-of-function mutations in patients lead to congenital indifference to pain, though it remains unclear where on the way from sensory terminals to central nervous system the signalling is disrupted. We co...
Topics
- Action Potentials
- Animals
- Calcitonin Gene-Related Peptide
- Disease Models, Animal
- Ganglia, Spinal
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel
- Nerve Fibers, Unmyelinated
- Pain
- Pain Measurement
- Pain Threshold
- Physical Stimulation
- Sensory Receptor Cells