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Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus

24 Nov 2017

Abstract excerpt

We report here that in rat and human neuroprogenitor cells as well as rat embryonic cortical neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by structural disruption of the nucleolus. The anti-nucleolar effects were most pronounced in postmitotic neurons. Moreover, in the latter system, nucleolar presence of ZIKV capsid protein (ZIKV-C) was associated with ribosomal stress and...

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PMID: 29192272
DOI: 10.1038/s41598-017-16952-8

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