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Article

Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast

3 Jan 2017

Abstract excerpt

The Zika virus (ZIKV) causes microcephaly and the Guillain-Barré syndrome. Little is known about how ZIKV causes these conditions or which ZIKV viral protein(s) is responsible for the associated ZIKV-induced cytopathic effects, including cell hypertrophy, growth restriction, cell-cycle dysregulation, and cell death. We used fission yeast for the rapid, global functional analysis of the ZIKV genome. All 14...

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PMID: 28049830
DOI: 10.1073/pnas.1619735114

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