Article
ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly.
Cell death & disease - 27 Oct 2016
Ghouzzi Vincent El, Bianchi Federico T, Molineris Ivan, Mounce Bryan C, Berto Gaia E, Rak Malgorzata, Lebon Sophie, Aubry Laetitia, Tocco Chiara, Gai Marta, Chiotto Alessandra Ma, Sgrò Francesco, Pallavicini Gianmarco, Simon-Loriere Etienne, Passemard Sandrine, Vignuzzi Marco, Gressens Pierre, Di Cunto Ferdinando
Abstract excerpt
Epidemiological evidence from the current outbreak of Zika virus (ZIKV) and recent studies in animal models indicate a strong causal link between ZIKV and microcephaly. ZIKV infection induces cell-cycle arrest and apoptosis in proliferating neural progenitors. However, the mechanisms leading to these phenotypes are still largely obscure. In this report, we explored the possible similarities between...
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