Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein

6 Nov 2018

Abstract excerpt

Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly. Using a human stem cell-derived neural progenitor model system, we find that a critical cellular quality control process called the nonsense-mediated mRNA decay (NMD) pathway is disrupted during ZIKV infection. Importantly, disruption of the NMD pathway is a known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30401782
DOI: 10.1128/mbio.02126-18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid ProteinPMID 30401782Read ↗

Genome-wide Integrative Analysis of Zika-Virus-Infected Neuronal Stem Cells Reveals Roles for MicroRNAs in Cell Cycle and StemnessSemantic proximity Read ↗

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesisSemantic proximity Read ↗

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA SignaturesSemantic proximity Read ↗

In silico analysis revealed Zika virus miRNAs associated with viral pathogenesis through alteration of host genes involved in immune response and neurological functionsSemantic proximity Read ↗

An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell DeathSemantic proximity Read ↗

ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cellsSemantic proximity Read ↗

Zika virus disrupts molecular fingerprinting of human neurospheresSemantic proximity Read ↗

Zika and Dengue Viruses Differentially Modulate Host mRNA Processing Factors Defining Its VirulenceSemantic proximity Read ↗

ZIKV Infection and miRNA Network in Pathogenesis and Immune ResponseSemantic proximity Read ↗

MicroRNA and mRNA Dysregulation in Astrocytes Infected with Zika VirusSemantic proximity Read ↗

Dysregulation of Long Non-coding RNA (lncRNA) Genes and Predicted lncRNA-Protein Interactions during Zika Virus InfectionSemantic proximity Read ↗

Noncoding RNA of Zika Virus Affects Interplay between Wnt-Signaling and Pro-Apoptotic Pathways in the Developing Brain TissueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.