Article
Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile.
Epigenetics & chromatin - 1 Dec 2017
Posukh Olga V, Maksimov Daniil A, Laktionov Petr P, Koryakov Dmitry E, Belyakin Stepan N
Abstract excerpt
BACKGROUND: In eukaryotes, heterochromatin replicates late in S phase of the cell cycle and contains specific covalent modifications of histones. SuUR mutation found in Drosophila makes heterochromatin replicate earlier than in wild type and reduces the level of repressive histone modifications. SUUR protein was shown to be associated with moving replication forks, apparently through the interaction with PCNA....
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