Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque).

The journal of trauma and acute care surgery - 1 Apr 2017

Macko Antoni R, Moore Hunter B, Cap Andrew P, Meledeo M Adam, Moore Ernest E, Sheppard Forest R

Abstract excerpt

BACKGROUND: Hypoperfusion is associated with hyperfibrinolysis and early death from exsanguination, whereas tissue trauma is associated with hypofibrinolysis and delayed death from organ failure. We sought to elucidate the effects of injury patterns on fibrinolysis phenotypes using a nonhuman primate (NHP) model. METHODS: NHPs were randomized to three injury groups (n = 8/group): 60 minutes severe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation Tests
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrinolysis

Share to Macaca mulatta

Share to Phenotype

Share to Random Allocation

Source

Open in PubMed Open full text

Identifiers

PMID: 28129263
DOI: 10.1097/TA.0000000000001379
PMCID: PMC5767102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque).PMID 28129263Read ↗

Injury Severity is a Key Contributor to Coagulation Dysregulation and Fibrinogen ConsumptionSemantic proximity Read ↗

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.Semantic proximity Read ↗

Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock.Semantic proximity Read ↗

Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.Semantic proximity Read ↗

Characterizing the impact of traumatic brain injury phenotype on coagulation dynamics in severely injured patients.Semantic proximity Read ↗

Severe traumatic brain injury is associated with a unique coagulopathy phenotypeSemantic proximity Read ↗

Differentiating Pathologic from Physiologic Fibrinolysis: Not as Simple as Conventional Thrombelastography.Semantic proximity Read ↗

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry.Semantic proximity Read ↗

The hyperfibrinolytic phenotype is the most lethal and resource intense presentation of fibrinolysis in massive transfusion patientsSemantic proximity Read ↗

Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury.Semantic proximity Read ↗

Variations in clot phenotype following injury: The MA-R ratio and fragile clots.Semantic proximity Read ↗

Plasma regulates homeostatic pulmonary endothelial signaling to mitigate vascular leak following polytrauma and hemorrhagic shockSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.