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Article

Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.

Transfusion - 1 Apr 2016

Moore Ernest E, Moore Hunter B, Gonzalez Eduardo, Sauaia Angela, Banerjee Anirban, Silliman Christopher C

Abstract excerpt

Postinjury fibrinolysis can manifest as three distinguishable phenotypes: 1) hyperfibrinolysis, 2) physiologic, and 3) hypofibrinolysis (shutdown). Hyperfibrinolysis is associated with uncontrolled bleeding due to clot dissolution; whereas, fibrinolysis shutdown is associated with organ dysfunction due to microvascular occlusion. The incidence of fibrinolysis phenotypes at hospital arrival in severely injured...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27100746
DOI: 10.1111/trf.13486
PMCID: PMC5688850

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