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Article

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells

29 Nov 2017

Abstract excerpt

Abstract Understanding the control of Ag restimulation-induced T cell death (RICD), especially in cancer immunotherapy, where highly proliferating T cells will encounter potentially large amounts of tumor Ags, is important now more than ever. It has been known that growth cytokines make T cells susceptible to RICD, but the precise molecular mediators that govern this in T cell subsets is unknown until now. STAT...

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PMID: 29187589
DOI: 10.4049/jimmunol.1701133

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