Article
Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006
Cohen Aileen C, Nadeau Kari C, Tu Wenwei, Hwa Vivian, Dionis Kira, Bezrodnik Liliana, Teper Alejandro, Gaillard Maria, Heinrich Juan, Krensky Alan M, Rosenfeld Ron G, Lewis David B
Abstract excerpt
We show that STAT5b is important for the in vivo accumulation of CD4+ CD25(high) T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4+ CD25(high) T cells. STAT5b(A630P/A630P) CD4+ CD25(high) T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4+...
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