Article
Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia.
Cancer immunology research - 1 Aug 2016
Ureshino Hiroshi, Shindo Takero, Nishikawa Hiroyoshi, Watanabe Nobukazu, Watanabe Eri, Satoh Natsuko, Kitaura Kazutaka, Kitamura Hiroaki, Doi Kazuko, Nagase Kotaro, Kimura Hiromi, Samukawa Makoto, Kusunoki Susumu, Miyahara Masaharu, Shin-I Tadasu, Suzuki Ryuji, Sakaguchi Shimon, Kimura Shinya
Abstract excerpt
The regulatory T cells (Treg) with the most potent immunosuppressive activity are the effector Tregs (eTreg) with a CD45RA(-)Foxp3(++)CCR4(+) phenotype. Adult T-cell leukemia (ATL) cells often share the Treg phenotype and also express CCR4. Although mogamulizumab, a monoclonal antibody to CCR4, shows marked antitumor effects against ATL and peripheral T-cell lymphoma, concerns have been raised that it may induce...
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