Article
Tissue-Specific Gene Inactivation in Xenopus laevis: Knockout of lhx1 in the Kidney with CRISPR/Cas9.
Genetics - 1 Feb 2018
DeLay Bridget D, Corkins Mark E, Hanania Hannah L, Salanga Matthew, Deng Jian Min, Sudou Norihiro, Taira Masanori, Horb Marko E, Miller Rachel K
Abstract excerpt
Studying genes involved in organogenesis is often difficult because many of these genes are also essential for early development. The allotetraploid frog, Xenopus laevis, is commonly used to study developmental processes, but because of the presence of two homeologs for many genes, it has been difficult to use as a genetic model. Few studies have successfully used CRISPR in amphibians, and currently there is no...
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