Article
Xenopus as a model organism for birth defects-Congenital heart disease and heterotaxy.
Seminars in cell & developmental biology - 1 Mar 2016
Duncan Anna R, Khokha Mustafa K
Abstract excerpt
Congenital heart disease is the leading cause of birth defects, affecting 9 out of 1000 newborns each year. A particularly severe form of congenital heart disease is heterotaxy, a disorder of left-right development. Despite aggressive surgical management, patients with heterotaxy have poor survival rates and severe morbidity due to their complex congenital heart disease. Recent genetic analysis of affected...
Topics
- Animals
- Body Patterning
- Disease Models, Animal
- Heterotaxy Syndrome
- Humans
- Mutation
- N-Acetylgalactosaminyltransferases
- NIMA-Related Kinases
- Proto-Oncogene Proteins
- Repressor Proteins
- Xenopus