Xenopus as a platform for discovery of genes relevant to human disease.

Abstract excerpt

Congenital birth defects result from an abnormal development of an embryo and have detrimental effects on children's health. Specifically, congenital heart malformations are a leading cause of death among pediatric patients and often require surgical interventions within the first year of life. Increased efforts to navigate the human genome provide an opportunity to discover multiple candidate genes in patients...

Topics

• Animals
• Congenital Abnormalities
• Genes
• Genomics
• Heart Defects, Congenital
• Humans
• Mutation
• Phenotype
• Xenopus laevis