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Article

Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer.

The American journal of pathology - 1 Aug 2002

Yoon Dae-Sung, Wersto Robert P, Zhou Weibo, Chrest Francis J, Garrett Elizabeth S, Kwon Teag Kyu, Gabrielson Edward

Abstract excerpt

Cytogenetic analyses have revealed that many aneuploid breast cancers have cell-to-cell variations of chromosome copy numbers, suggesting that these neoplasms have instability of chromosome numbers. To directly test for possible chromosomal instability in this disease, we used fluorescent in situ hybridization to monitor copy numbers of multiple chromosomes in cultures of replicating breast cancer-derived cell...

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Identifiers

PMID: 12163363
DOI: 10.1016/S0002-9440(10)64194-6
PMCID: PMC1850727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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