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Article

An endothelial regulatory module links blood pressure regulation with elite athletic performance.

PLoS genetics - 1 Jun 2024

Fegraeus Kim, Rosengren Maria K, Naboulsi Rakan, Orlando Ludovic, Åbrink Magnus, Jouni Ahmad, Velie Brandon D, Raine Amanda, Egner Beate, Mattsson C Mikael, Lång Karin, Zhigulev Artemy, Björck Hanna M, Franco-Cereceda Anders, Eriksson Per, Andersson Göran, Sahlén Pelin, Meadows Jennifer R S, Lindgren Gabriella

Abstract excerpt

The control of transcription is crucial for homeostasis in mammals. A previous selective sweep analysis of horse racing performance revealed a 19.6 kb candidate regulatory region 50 kb downstream of the Endothelin3 (EDN3) gene. Here, the region was narrowed to a 5.5 kb span of 14 SNVs, with elite and sub-elite haplotypes analyzed for association to racing performance, blood pressure and plasma levels of EDN3 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38885195
DOI: 10.1371/journal.pgen.1011285
PMCID: PMC11182536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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