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Article

Using imputed genotype data in the joint score tests for genetic association and gene-environment interactions in case-control studies.

Genetic epidemiology - 1 Mar 2018

Song Minsun, Wheeler William, Caporaso Neil E, Landi Maria Teresa, Chatterjee Nilanjan

Abstract excerpt

Genome-wide association studies (GWAS) are now routinely imputed for untyped single nucleotide polymorphisms (SNPs) based on various powerful statistical algorithms for imputation trained on reference datasets. The use of predicted allele counts for imputed SNPs as the dosage variable is known to produce valid score test for genetic association. In this paper, we investigate how to best handle imputed SNPs in...

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PMID: 29178451
DOI: 10.1002/gepi.22093
PMCID: PMC5811375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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