Article
Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism.
The Journal of antimicrobial chemotherapy - 1 Feb 2018
Paloque Lucie, Witkowski Benoit, Lelièvre Joël, Ouji Manel, Ben Haddou Tanila, Ariey Frédéric, Robert Anne, Augereau Jean-Michel, Ménard Didier, Meunier Bernard, Benoit-Vical Françoise
Abstract excerpt
Background: Owing to the emergence of multiresistant Plasmodium falciparum parasites in Southeast Asia, along with the impressive decrease in the efficacy of the endoperoxide compound artemisinin and of artemisinin-based combination therapies, the development of novel antimalarial drugs or combinations is required. Although several antiplasmodial molecules, such as endoperoxide-based compounds, are in advanced...
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