Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo.

doi:10.1159/000485361

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Article

Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2017

Dibué-Adjei Maxine, Kamp Marcel A, Alpdogan Serdar, Tevoufouet Etienne E, Neiss Wolfram F, Hescheler Jürgen, Schneider Toni

Abstract excerpt

BACKGROUND/AIMS: Lamotrigine (LTG) is a popular modern antiepileptic drug (AED), however, its mechanism of action has yet to be fully understood, as it is known to modulate many members of several ion channel families. In heterologous systems, LTG inhibits Cav2.3 (R-type) calcium currents, which contribute to kainic-acid- (KA) induced epilepsy in vivo. To gain insight into the role of R-type currents in LTG drug...

Topics

Acetamides
Animals
Anticonvulsants
Behavior, Animal
Calcium Channels, R-Type
Electrocorticography
Epilepsy
Fructose
Genotype
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kainic Acid

Lacosamide

Lamotrigine

Mice

Mice, Inbred C57BL

Mice, Knockout

Neuroprotective Agents

Pyramidal Cells

Source

Open in PubMed

Identifiers

PMID: 29176325
DOI: 10.1159/000485361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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