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Article

Alzheimer's disease-associated ubiquitin mutant Ubb+1: Properties of the carboxy-terminal domain and its influence on biomolecular interactions.

International journal of biological macromolecules - 1 Mar 2018

Munari Francesca, Bortot Andrea, Assfalg Michael, D'Onofrio Mariapina

Abstract excerpt

Ubb+1, a ubiquitin (Ub) mutant protein originating from misreading of the Ub B gene, is found accumulated in brain tissues of Alzheimer's disease patients. The mutant attracts strong interest due to its possible participation in the molecular events leading to neurodegeneration. Ubb+1 is composed of the globular domain of Ub, linked to a 19-residue C-terminal peptide. Based on NMR relaxation and solvent...

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Source

Identifiers

PMID: 29175520
DOI: 10.1016/j.ijbiomac.2017.11.121

Genes

UBA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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