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Article

Aggregation Pathways of Native-Like Ubiquitin Promoted by Single-Point Mutation, Metal Ion Concentration, and Dielectric Constant of the Medium.

Chemistry (Weinheim an der Bergstrasse, Germany) - 15 Mar 2018

Fermani Simona, Calvaresi Matteo, Mangini Vincenzo, Falini Giuseppe, Bottoni Andrea, Natile Giovanni, Arnesano Fabio

Abstract excerpt

Ubiquitin-positive protein aggregates are biomarkers of neurodegeneration, but the molecular mechanism responsible for their formation and accumulation is still unclear. Possible aggregation pathways of human ubiquitin (hUb) promoted by both intrinsic and extrinsic factors, are here investigated. By a computational analysis, two different hUb dimers are indicated as possible precursors of amyloid-like structures,...

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Identifiers

PMID: 29266436
DOI: 10.1002/chem.201705543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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