Article
Structural characterization of a mutant peptide derived from ubiquitin: implications for protein folding.
Protein science : a publication of the Protein Society - 1 Nov 2000
Zerella R, Chen P Y, Evans P A, Raine A, Williams D H
Abstract excerpt
The formation of the N-terminal beta-hairpin of ubiquitin is thought to be an early event in the folding of this small protein. Previously, we have shown that a peptide corresponding to residues 1-17 of ubiquitin folds autonomously and is likely to have a native-like hairpin register. To investigate the causes of the stability of this fold, we have made mutations in the amino acids at the apex of the turn. We...
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