Article
Heat capacity changes upon burial of polar and nonpolar groups in proteins.
Protein science : a publication of the Protein Society - 1 Jul 2001
Loladze V V, Ermolenko D N, Makhatadze G I
Abstract excerpt
In this paper we address the question of whether the burial of polar and nonpolar groups in the protein locale is indeed accompanied by the heat capacity changes, DeltaC(p), that have an opposite sign, negative for nonpolar groups and positive for polar groups. To accomplish this, we introduced amino acid substitutions at four fully buried positions of the ubiquitin molecule (Val5, Val17, Leu67, and Gln41). We...
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