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Article

The effect of Parkinson's-disease-associated mutations on the deubiquitinating enzyme UCH-L1.

Journal of molecular biology - 25 Mar 2011

Andersson Fredrik I, Werrell Elizabeth F, McMorran Lindsay, Crone William J K, Das Chittarnajan, Hsu Shang-Te Danny, Jackson Sophie E

Abstract excerpt

The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been linked to Parkinson's disease (PD) and other neurodegenerative diseases. Here, we present a study on the structure, stability, unfolding, and dynamics of wild-type and mutant UCH-L1. Fluorescence, far-UV CD, and NMR measurements were used to establish that the unfolding of UCH-L1 is three-state under equilibrium conditions and that an intermediate...

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Identifiers

PMID: 21251915
DOI: 10.1016/j.jmb.2010.12.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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