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Article

Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.

Human immunology - 1 Feb 2018

Guimarães Lilian O, Bajay Miklos Maximiliano, Monteiro Eliana F, Wunderlich Gerhard, Santos Sidney E, Kirchgatter Karin

Abstract excerpt

The innate immune system governed by toll-like receptors (TLRs) provides the first line of defense against pathogens. Surface-localized TLR1 and TLR6 are known to detect parasite components. TLR encoding genes were shown to display signatures of recent positive selection in Europeans and might be involved in local adaptation at immune-related genes. To verify the influence of Brazilian population admixture on the...

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Source

Identifiers

PMID: 29175392
DOI: 10.1016/j.humimm.2017.11.007

Genes

TLR1
TLR6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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