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Article

Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase.

Nucleic acids research - 15 Dec 2017

Remus Barbara S, Goldgur Yehuda, Shuman Stewart

Abstract excerpt

Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2',3'-cyclic-PO4 and 5'-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodiesterase and central polynucleotide kinase domains that heal the broken ends to generate the 3'-OH,2'-PO4 and 5'-PO4 termini required for sealing by an...

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Identifiers

PMID: 29165709
DOI: 10.1093/nar/gkx1159
PMCID: PMC5728400

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