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Article

Structure-function analysis of yeast tRNA ligase.

RNA (New York, N.Y.) - 1 Jun 2005

Wang Li Kai, Shuman Stewart

Abstract excerpt

Trl 1 is an essential 827-amino-acid enzyme that executes the end-healing and end-sealing steps of tRNA splicing in Saccharomyces cerevisiae. Trl1 consists of two catalytic domains--an N-terminal adenylyltransferase/ligase component (amino acids 1-388) and a C-terminal 5'-kinase/cyclic phosphodiesterase component (amino acids 389-827)--that can function in tRNA splicing in vivo when expressed as separate...

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PMID: 15923379
DOI: 10.1261/rna.2170305
PMCID: PMC1370781

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