Article
Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.
Nucleic acids research - 13 Oct 2017
Gonzalez Grecia M, Durica-Mitic Svetlana, Hardwick Steven W, Moncrieffe Martin C, Resch Marcus, Neumann Piotr, Ficner Ralf, Görke Boris, Luisi Ben F
Abstract excerpt
In phylogenetically diverse bacteria, the conserved protein RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism. RapZ contributes to the control of glucosamine phosphate biogenesis by selectively presenting the regulatory small RNA GlmZ to the essential ribonuclease RNase E for inactivation. Here, we report the crystal structures of full length Escherichia coli RapZ at 3.40 Å and 3.25...
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