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Article

CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation.

Autophagy - 1 Jan 2018

Mishra Shrawan Kumar, Gao Yong-Guang, Deng Yibin, Chalfant Charles E, Hinchcliffe Edward H, Brown Rhoderick E

Abstract excerpt

The macroautophagy/autophagy and inflammasome pathways are linked through their roles in innate immunity and chronic inflammatory disease. Ceramide-1-phosphate (C1P) is a bioactive sphingolipid that regulates pro-inflammatory eicosanoid production. Whether C1P also regulates autophagy and inflammasome assembly/activation is not known. Here we show that CPTP (a protein that traffics C1P from its site of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29164996
DOI: 10.1080/15548627.2017.1393129
PMCID: PMC6070007

Genes

CPTP
ATG5
ATG7
CASP1
GLTP
MTOR
NLRC4
NLRP3
SQSTM1
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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