Article
Study of mutations in IDH1 and IDH2 genes in a sample of gliomas from Colombian population
Biomedica : revista del Instituto Nacional de Salud - 1 May 2018
Ricaurte Orlando, Neita Karina, Valero Danyela, Ortega-Rojas Jenny, Arboleda-Bustos Carlos E, Zubieta Camilo, Penagos José, Arboleda Gonzalo
Abstract excerpt
Introduction: Gliomas are the most common primary tumors of the central nervous system and, according to their malignancy, they are graded from I to IV. Recent studies have found that there is an association between gliomas and mutations in exon 4 of genes that codify for isocitrate dehydrogenases 1 and 2 (IDH1: codon 132; IDH2: codon 172). Objective: To establish the frequency of mutations in IDH1 and IDH2 in a...
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