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TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression

26 Dec 2024

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is frequently hyperactivated in triple-negative breast cancers (TNBCs) associated with poor prognosis and is a therapeutic target in breast cancer management. Here, we describe the effects of repression of mTOR-containing complex 1 (mTORC1) through knockdown of several key mTORC1 components or with mTOR inhibitors used in...

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PMID: 39729986
DOI: 10.1016/j.devcel.2024.12.005

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