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Article

Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1

9 Jun 2009

Abstract excerpt

An understanding of the mechanisms that govern pancreatic endocrine cell ontogeny may offer strategies for their somatic replacement in diabetic patients. During embryogenesis, transcription factor FoxO1 is expressed in pancreatic progenitor cells. Subsequently, it becomes restricted to beta cells and to a rare population of insulin-negative juxtaductal cells (FoxO1+ Ins(-)). It is unclear whether FoxO1+ Ins(-)...

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PMID: 19506018
DOI: 10.1128/mcb.01622-08

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