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microRNA-181c-5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2

15 Jun 2020

Abstract excerpt

Generating insulin-producing cells (IPCs) from human pluripotent stem cells is a promising method for studying the molecular mechanism underlying pancreas development and a potential treatment source for type 1 diabetes. Previous studies have shown that miR-181c-5p is highly enriched in adult islets; however, its role in pancreatic β cell differentiation is poorly understood. In this study, we differentiated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32541687
DOI: 10.1038/s41419-020-2668-9

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