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Article

A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks.

PLoS computational biology - 1 Jun 2020

López-Agudelo Víctor A, Mendum Tom A, Laing Emma, Wu HuiHai, Baena Andres, Barrera Luis F, Beste Dany J V, Rios-Estepa Rigoberto

Abstract excerpt

Metabolism underpins the pathogenic strategy of the causative agent of TB, Mycobacterium tuberculosis (Mtb), and therefore metabolic pathways have recently re-emerged as attractive drug targets. A powerful approach to study Mtb metabolism as a whole, rather than just individual enzymatic components, is to use a systems biology framework, such as a Genome-Scale Metabolic Network (GSMN) that allows the dynamic...

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Identifiers

PMID: 32542021
DOI: 10.1371/journal.pcbi.1007533
PMCID: PMC7316355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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