Article
Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis.
Molecular systems biology - 1 May 2021
Borah Khushboo, Mendum Tom A, Hawkins Nathaniel D, Ward Jane L, Beale Michael H, Larrouy-Maumus Gerald, Bhatt Apoorva, Moulin Martine, Haertlein Michael, Strohmeier Gernot, Pichler Harald, Forsyth V Trevor, Noack Stephan, Goulding Celia W, McFadden Johnjoe, Beste Dany J V
Abstract excerpt
The co-catabolism of multiple host-derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, the metabolic plasticity of this pathogen and the complexity of the metabolic networks present a major obstacle in identifying those nodes most amenable to therapeutic interventions. It is therefore critical that we define the metabolic phenotypes...
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