Article
MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.
Journal of the National Cancer Institute - 1 May 2018
Walker Christopher J, Rush Craig M, Dama Paola, O'Hern Matthew J, Cosgrove Casey M, Gillespie Jessica L, Zingarelli Roman A, Smith Blair, Stein Maggie E, Mutch David G, Shakya Reena, Chang Chia-Wen, Selvendiran Karuppaiyah, Song Jonathan W, Cohn David E, Goodfellow Paul J
Abstract excerpt
Background: Genomic studies have revealed that multiple genes are mutated at varying frequency in endometrial cancer (EC); however, the relevance of many of these mutations is poorly understood. An EC-specific recurrent mutation in the MAX transcription factor p.His28Arg was recently discovered. We sought to assess the functional consequences of this hotspot mutation and determine its association with...
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